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Description: Critical Illness Immunological Reprogramming and Control Point Learning Engine CIRCLE Innovative Solutions Opening ISO District of Columbia (DC) \| Solicitation If online, then find more information EXTERNAL LINK Event Date 28 May, 2026 The agency sponsor is System for Award Managed (SAM) The reference for this notice (if available) ARPA-H-SOL-26-139 Agency Contact Information Agency Procurement Site EXTERNAL LINK Primary Contact Person Contracting Officer Primary Contact Email Primary Contact Number NAICS Code 541715 Setaside No Set aside used PSC Code AN13 Summary Information About This Opportunity The Advanced Research Projects Agency for Health (ARPA-H) is posting this Innovative Solutions Opening (ISO) solicitation in support of the Critical Illness Immunological Reprogramming and Control Point Learning Engine (CIRCLE) Program. ARPA-H anticipates that multiple Other Transaction (OT) Agreements will result from this announcement. CIRCLE seeks to create a critical illness Control Point Validation Engine that leads to improvements in intensive care unit (ICU) health outcomes, coupled to reduced stay time and associated costs, by assessing, predicting, and treating immuno-inflammatory dysregulation before it causes organ failure. Interested parties are invited to review the attached CIRCLE ISO ARPA-H-SOL-26-139 and its Attachments A – F. Proposer's Day: Wednesday, March 11, 2026 (ARPA-H-SN-26-149) Solution Summaries Due: Monday, March 30, 2026, 1 PM ET (to https://solutions.arpa-h.gov) Questions Due: Friday, May 22, 2026, 1 PM ET (to https://solutions.arpa-h.gov/Ask-A-Question/) Full Proposals Due: Thursday, May 28, 2026, 1 PM ET (to https://solutions.arpa-h.gov) ARPA-H will not reimburse potential proposers for time and effort related to submission of solution summaries or proposals. When planning a response to this notice, proposers should consider that some parts of the submission process may take from one business day to one month to complete. -------------------------- Amendment 1 -------------------------- The purpose of this amendment is to: change the proposal submission date to Thursday, May 28, 2026 and replace Office of Commercialization (OC) with ARPA-H. Competitive Intelligence and Special Notes This bid has not yet been classified by our system since the NAICS code did not match but is available at SAM.gov.